Work in Excel
Here's a quick walk-through of Excel for the web. You'll find it's pretty straightforward and similar to what you're used to.
Name your file
At the top, you'll notice that Excel for the web automatically names your workbook Book1 (or Book2, or Book3...). To give it a more meaningful name:
Click the current name.
Type a name that works for you.
Keep in mind that anything you do in Excel for the web — from naming the file, to working in the cells — is saved automatically, just like in Sheets.
Do your work
After you've named your file, you can do what you usually do: enter data, add formatting, type formulas, make charts, and so on. All features are available to you on the tabs at the top.
If you find the tabs are taking up too much space, double-click a tab and the ribbon collapses to give you more room.
Edit using the desktop app
If you find Excel for the web is missing something you need, you can always edit the file in the full Excel desktop application. To switch to the desktop app:
Click Edit in Excel.
The Excel app will launch and open the file.
When your changes are saved in the application, they get saved to OneDrive. There's no need to do a "Save As" and re-upload the file.