You can remove Skype for Business from your computer in just a few steps.
Step 1: Stop Skype for Business from starting automatically
In Skype for Business, choose the tools icon and Tools > Options.
Choose Personal, then uncheck Automatically start the app when I log on to Windows and Start the app in the foreground. Then choose OK.
Choose File > Exit.
Skype for Business is still on your computer, but you'll no longer see it. Some people stop here because they're happy with just not having Skype for Business start.
Step 2: Remove Skype for Business from your computer
Go to Control Panel > Programs > Programs and Features > Uninstall or change a program.
Choose Skype for Business > Uninstall.
If you don't see Skype for Business listed, see Why can't I uninstall Skype for Business?
At the Ready to uninstall? box, choose Uninstall.
The Office dialog box says "We're removing Office from your computer now" but it's only removing Skype for Business, not other Office applications you may have installed on your computer. If you have other Office applications open, such as Excel or Outlook, you'll be prompted to close them.
Skype for Business is integrated with other Office applications so the Office installer needs to update them to remove Skype for Business features. This can take several minutes.
When it's done uninstalling, choose Close.
Restart your computer.
Remove Skype for Business from your registry
If the above instructions don't work for you, then another option is to disable it in your registry. For instructions, see this post in the Skype community: Completely Uninstall Skype for Business.
Why can't I uninstall Skype for Business from my computer?
If your business purchased the Office 365 ProPlus plan, then you can't uninstall Skype for Business without uninstalling all of Office. Some businesses choose this option because they want everyone to install and use all of the Office apps.
Here's what you need to do: Contact the person who purchased Office 365 for your business and tell them you want to uninstall Skype for Business. They can switch to a different Office 365 plan, and you'll be able to remove Skype for Business from your computer but keep the other Office apps.
You can uninstall Skype for Business on Mac so you don't see it on your Dock in a few easy steps.
To uninstall Skype for Business on Mac
To remove the Skype for Business icon from your Dock, sign out of Skype for Business on Mac.
Close the Skype for Business on Mac sign in page.
Press Control and click at the same time. Choose Quit.
Open Finder > Applications. Scroll to Skype for Business. Drag and drop it into the Trash.